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rat parathyroid hormone (pth 1-34)  (Bachem)

 
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    Bachem rat parathyroid hormone (pth 1-34)
    Rat Parathyroid Hormone (Pth 1 34), supplied by Bachem, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/pth(1%E2%80%9334)%2C+rat/parathyroid+hormone++pth+/pm40609791-153-0-8
    Average 90 stars, based on 1 article reviews
    rat parathyroid hormone (pth 1-34) - by Bioz Stars, 2026-09
    90/100 stars

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    Mass Spectrometry:

    Article Title: PTH stimulation of Rankl transcription is regulated by SIK2 and 3 and mediated by CRTC2 and 3 through action of protein phosphatases 1, 2, 4, and 5.
    Article Snippet: .. Rat parathyroid hormone (PTH 1-34) was purchased from Bachem, which was confirmed and analyzed for purity and degradation by NYU Grossman School of Medicine Mass Spectrometry Core Facility. ..

    other:

    Article Title: PTHrP promotes subchondral bone formation in TMJ-OA
    Article Snippet: For pharmacological treatment, 30 days after surgery, the 20 rats in the TMJ-OA group were randomly selected, and some received subcutaneous injections of PTHrP (recombinant human PTH 1–34, Bachem California, Inc., King of Prussia, n = 10 rats), while other received PBS (1 mmol·L −1 acetic acid in phosphate-buffered saline, n = 10 rats) daily for an equivalent volume of PTH daily, the injections performed continuously for 5 days, and then suspend for 2 days before the other 5 days injection, then 2 days suspending.

    Article Title: Increased osteoblast GαS level determines bone response to hyperparathyroidism in female mice.
    Article Snippet: Primary osteoblasts in 96-well collagen-coated E-plate VIEW plates (ACEA Biosciences Inc., San Diego, CA, USA) on day 7 after subculture were serum-starved for 4 h prior to dosing with 10−11 to 10−6 M rat PTH1–34 (Bachem, Torrance, CA, USA).

    Article Title: MDS cells impair osteolineage differentiation of MSCs via extracellular vesicles to suppress normal hematopoiesis.
    Article Snippet: Rat PTH(1–34) (Bachem, Bubendorf, Switzerland) was dissolved in PBS, and 80 mg/kg body weight rat PTH(1–34) was administered intraperitoneally using a 5-days on/2-days off schedule.

    Article Title: Gender-Specific Differences in the Skeletal Response to Continuous PTH in Mice Lacking the IGF1 Receptor in Mature Osteoblasts
    Article Snippet: We infused 12-week-old female and male mice with continuous rat PTH 1–34 (Bachem, Torrance, CA, USA) at a dose of 60 μg/kg body weight or vehicle solution via ALZET mini osmotic pumps (Model 1004) over a period of 4 weeks.

    Article Title: Extracellular nucleotides enhance agonist potency at the parathyroid hormone 1 receptor.
    Article Snippet: Accepted Manuscript Extracellular nucleotides enhance agonist potency at the parathyroid hormone 1 receptor Brandon H. Kim, Alexey Pereverzev, Shuying Zhu, Abby Oi Man Tong, S. Jeffrey Dixon, Peter Chidiac PII: S0898-6568(18)30062-7 DOI: doi:10.1016/j.cellsig.2018.02.015 Reference: CLS 9084 To appear in: Cellular Signalling Received date: 10 February 2018 Revised date: 26 February 2018 Accepted date: 28 February 2018 Please cite this article as: Brandon H. Kim, Alexey Pereverzev, Shuying Zhu, Abby Oi Man Tong, S. Jeffrey Dixon, Peter Chidiac , Extracellular nucleotides enhance agonist potency at the parathyroid hormone 1 receptor.. The address for the corresponding author was captured as affiliation for all authors.. Please check if appropriate.

    Article Title: Intermittent PTH treatment improves bone and muscle in glucocorticoid treated Mdx mice: A model of Duchenne Muscular Dystrophy.
    Article Snippet: Duchenne Muscular Dystrophy (DMD) is a progressive muscle disorder caused by genetic mutations of the dystrophin encoding gene.. In the absence of functional dystrophin, DMD patients suffer from muscle inflammation and wasting, as well as compromised bone health with increased risk of fracture.. The use of high dose glucocorticoids (GC) as the standard therapy also contributes to bone fragility.

    Article Title: Gender-Specific Differences in the Skeletal Response to Continuous PTH in Mice Lacking the IGF1 Receptor in Mature Osteoblasts
    Article Snippet: Continuous PTH infusion We infused 12-week-old female and male mice with continuous rat PTH 1–34 (Bachem, Torrance, CA, USA) at a dose of 60 μg/kg body weight or vehicle solution via ALZET mini osmotic pumps (Model 1004) over a period of 4 weeks.



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    IGF-IR is required for the actions of PTH on bone mass. Fat-free weight/body weight (FFW/BW) of tibia in IGF-I receptor osteoblast null (IGF-IR OBKO, hatched bars) mice was significantly less (*p < 0.05) than that in control mice (open bars). PTH significantly (#p < 0.05) decreased FFW/BW of tibia in control mice, but not in IGF-IR OBKO mice, although the same trend was observed. Results are expressed as means ± SD: n = 7 (four males and three females) in the vehicle-treated control group and n = 9 (four males and five females) in the other groups.

    Journal: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

    Article Title: IGF-I Receptor Is Required for the Anabolic Actions of Parathyroid Hormone on Bone

    doi: 10.1359/jbmr.070517

    Figure Lengend Snippet: IGF-IR is required for the actions of PTH on bone mass. Fat-free weight/body weight (FFW/BW) of tibia in IGF-I receptor osteoblast null (IGF-IR OBKO, hatched bars) mice was significantly less (*p < 0.05) than that in control mice (open bars). PTH significantly (#p < 0.05) decreased FFW/BW of tibia in control mice, but not in IGF-IR OBKO mice, although the same trend was observed. Results are expressed as means ± SD: n = 7 (four males and three females) in the vehicle-treated control group and n = 9 (four males and five females) in the other groups.

    Article Snippet: Twelve-week-old control mice and mice with an osteoblast-specific IGF-IR –null mutation were treated with either PTH [lsqb]PTH(1–34), rat; Bachem[rsqb] 80 μg/kg body weight (BW) or vehicle (150 mM NaCl, 1 mM 1 N HCl, and 2% heat-inactivated FBS dissolved in distilled water) everyday by subcutaneous injection for 2 wk.

    Techniques: Control

    Role of IGF-IR in mediating the response of PTH on bone structure. Trabecular bone volume (BV) and cortical bone thickness (C. Th; *p < 0.05) were less in IGF-I receptor osteoblast null (IGF-IR OBKO) mice (hatched bars) than in control mice (open bars). PTH significantly decreased BV by 22% (#p < 0.05) and increased C.Th by 18% (#p < 0.05) in control mice, but had less effect in IGF-IR OBKO mice, although the trends were comparable. Results were determined by μCT and expressed as means ± SD: n = 7 (four males and three females) in the vehicle-treated control group and n = 9 (four males and five females) in the other groups.

    Journal: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

    Article Title: IGF-I Receptor Is Required for the Anabolic Actions of Parathyroid Hormone on Bone

    doi: 10.1359/jbmr.070517

    Figure Lengend Snippet: Role of IGF-IR in mediating the response of PTH on bone structure. Trabecular bone volume (BV) and cortical bone thickness (C. Th; *p < 0.05) were less in IGF-I receptor osteoblast null (IGF-IR OBKO) mice (hatched bars) than in control mice (open bars). PTH significantly decreased BV by 22% (#p < 0.05) and increased C.Th by 18% (#p < 0.05) in control mice, but had less effect in IGF-IR OBKO mice, although the trends were comparable. Results were determined by μCT and expressed as means ± SD: n = 7 (four males and three females) in the vehicle-treated control group and n = 9 (four males and five females) in the other groups.

    Article Snippet: Twelve-week-old control mice and mice with an osteoblast-specific IGF-IR –null mutation were treated with either PTH [lsqb]PTH(1–34), rat; Bachem[rsqb] 80 μg/kg body weight (BW) or vehicle (150 mM NaCl, 1 mM 1 N HCl, and 2% heat-inactivated FBS dissolved in distilled water) everyday by subcutaneous injection for 2 wk.

    Techniques: Control

    Role of IGF-IR in mediating the response of PTH on trabecular bone volume and formation. At the primary spongiosa, trabecular bone volume (BV/TV; *p < 0.05) was less in IGF-IR OBKO mice (A3, hatched bars in B) than in control mice (A1, open bars in B). PTH significantly increased BV/TV control mice (A2, open bars in B), but had less effect at the primary spongiosa of IGF-IR OBKO mice (A4, hatched bars in B). At the secondary spongiosa, PTH had less effect on BV/TV of both control (C, open bars) and IGF-IR OBKO (C, hatched bars). Trabecular bone formation rate (BFR/BS) significantly (*p < 0.05) decreased in the IGF-IR OBKO mice (D, hatched bars) than control mice (D, open bars). PTH stimulated BFR/BS in both control mice (*p < 0.05) and IGF-IR OBKO mice (#p < 0.05). There were no significant differences on mineral apposition rate (MAR) between control mice (E, open bars) and IGF-IR OBKO mice (E, hatched bars). PTH stimulated MAR only in the control mice (*p < 0.05). Results were determined by bone histomorphometry, expressed as means ± SD: n = 8 (four males and four females) in each group.

    Journal: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

    Article Title: IGF-I Receptor Is Required for the Anabolic Actions of Parathyroid Hormone on Bone

    doi: 10.1359/jbmr.070517

    Figure Lengend Snippet: Role of IGF-IR in mediating the response of PTH on trabecular bone volume and formation. At the primary spongiosa, trabecular bone volume (BV/TV; *p < 0.05) was less in IGF-IR OBKO mice (A3, hatched bars in B) than in control mice (A1, open bars in B). PTH significantly increased BV/TV control mice (A2, open bars in B), but had less effect at the primary spongiosa of IGF-IR OBKO mice (A4, hatched bars in B). At the secondary spongiosa, PTH had less effect on BV/TV of both control (C, open bars) and IGF-IR OBKO (C, hatched bars). Trabecular bone formation rate (BFR/BS) significantly (*p < 0.05) decreased in the IGF-IR OBKO mice (D, hatched bars) than control mice (D, open bars). PTH stimulated BFR/BS in both control mice (*p < 0.05) and IGF-IR OBKO mice (#p < 0.05). There were no significant differences on mineral apposition rate (MAR) between control mice (E, open bars) and IGF-IR OBKO mice (E, hatched bars). PTH stimulated MAR only in the control mice (*p < 0.05). Results were determined by bone histomorphometry, expressed as means ± SD: n = 8 (four males and four females) in each group.

    Article Snippet: Twelve-week-old control mice and mice with an osteoblast-specific IGF-IR –null mutation were treated with either PTH [lsqb]PTH(1–34), rat; Bachem[rsqb] 80 μg/kg body weight (BW) or vehicle (150 mM NaCl, 1 mM 1 N HCl, and 2% heat-inactivated FBS dissolved in distilled water) everyday by subcutaneous injection for 2 wk.

    Techniques: Control

    IGF-IR mediates the stimulation by PTH of periosteal and endosteal bone formation at the tibiofibular junction (TFJ). Periosteal bone formation rate (Peri. BFR) (A) and mineral apposition rate (Peri. MAR) (B) were significantly lower in IGF-I receptor osteoblast null mice (IGF-IR OBKO, hatched bars) than in control mice (open bars). PTH tended to increase Peri.BFR (A) and Peri.MAR (B) in control mice (p = 0.58), but had no effect in the IGF-IR OBKO mice. Endosteal (Endo.) BFR (C), and MAR (D) were comparable in control and IGF-IR OBKO mice. PTH significantly increased Endo.BFR and Endo.MAR in control mice but not in IGF-IR OBKO mice. Results were determined by bone histomorphometry using double label tetracycline and expressed as means ± SD. *p < 0.05 vs. vehicle-treated control mice. n = 7 (four males and three females) in the vehicle-treated control group and n = 9 (four males and five females) in the other groups.

    Journal: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

    Article Title: IGF-I Receptor Is Required for the Anabolic Actions of Parathyroid Hormone on Bone

    doi: 10.1359/jbmr.070517

    Figure Lengend Snippet: IGF-IR mediates the stimulation by PTH of periosteal and endosteal bone formation at the tibiofibular junction (TFJ). Periosteal bone formation rate (Peri. BFR) (A) and mineral apposition rate (Peri. MAR) (B) were significantly lower in IGF-I receptor osteoblast null mice (IGF-IR OBKO, hatched bars) than in control mice (open bars). PTH tended to increase Peri.BFR (A) and Peri.MAR (B) in control mice (p = 0.58), but had no effect in the IGF-IR OBKO mice. Endosteal (Endo.) BFR (C), and MAR (D) were comparable in control and IGF-IR OBKO mice. PTH significantly increased Endo.BFR and Endo.MAR in control mice but not in IGF-IR OBKO mice. Results were determined by bone histomorphometry using double label tetracycline and expressed as means ± SD. *p < 0.05 vs. vehicle-treated control mice. n = 7 (four males and three females) in the vehicle-treated control group and n = 9 (four males and five females) in the other groups.

    Article Snippet: Twelve-week-old control mice and mice with an osteoblast-specific IGF-IR –null mutation were treated with either PTH [lsqb]PTH(1–34), rat; Bachem[rsqb] 80 μg/kg body weight (BW) or vehicle (150 mM NaCl, 1 mM 1 N HCl, and 2% heat-inactivated FBS dissolved in distilled water) everyday by subcutaneous injection for 2 wk.

    Techniques: Control

    IGF-IR is required for PTH to stimulate osteoprogenitor cell proliferation and differentiation. The numbers of ALP+ colonies at day 14 of culture are equivalent in BMSCs from IGF-I receptor osteoblast null (IGF-IR OBKO) mice and controls. However, PTH increased the number of these colonies only in the controls (A). Subsequent mineralization (calcium nodules staining by alizarin red) of these colonies from the IGF-IR OBKO mice by day 28 was markedly decreased. PTH significantly increased mineralization on day 28 in BMSCs from control mice but not in BMSCs from IGF-IR OBKO mice. Results are expressed as means ± SD. *p < 0.05 vs. vehicle-treated control mice. n = 4 (three males and one female) in the vehicle-treated control and IGF-IR OBKO mice; n = 6 (three males and three females) in PTH-treated control mice; and n = 5 (three males and two females) in PTH-treated IGF-IR OBKO mice.

    Journal: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

    Article Title: IGF-I Receptor Is Required for the Anabolic Actions of Parathyroid Hormone on Bone

    doi: 10.1359/jbmr.070517

    Figure Lengend Snippet: IGF-IR is required for PTH to stimulate osteoprogenitor cell proliferation and differentiation. The numbers of ALP+ colonies at day 14 of culture are equivalent in BMSCs from IGF-I receptor osteoblast null (IGF-IR OBKO) mice and controls. However, PTH increased the number of these colonies only in the controls (A). Subsequent mineralization (calcium nodules staining by alizarin red) of these colonies from the IGF-IR OBKO mice by day 28 was markedly decreased. PTH significantly increased mineralization on day 28 in BMSCs from control mice but not in BMSCs from IGF-IR OBKO mice. Results are expressed as means ± SD. *p < 0.05 vs. vehicle-treated control mice. n = 4 (three males and one female) in the vehicle-treated control and IGF-IR OBKO mice; n = 6 (three males and three females) in PTH-treated control mice; and n = 5 (three males and two females) in PTH-treated IGF-IR OBKO mice.

    Article Snippet: Twelve-week-old control mice and mice with an osteoblast-specific IGF-IR –null mutation were treated with either PTH [lsqb]PTH(1–34), rat; Bachem[rsqb] 80 μg/kg body weight (BW) or vehicle (150 mM NaCl, 1 mM 1 N HCl, and 2% heat-inactivated FBS dissolved in distilled water) everyday by subcutaneous injection for 2 wk.

    Techniques: Staining, Control